Effects of locally applied Insulin-like Growth Factor-I on osseointegration
Med. oral patol. oral cir. bucal (Internet)
; 24(5): e652-e658, sept. 2019. ilus, graf
Article
En
| IBECS
| ID: ibc-185684
:
ES1.1
: BNCS
Background:
The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones. Material andMethods:
16 rabbits were randomly distributed into two groups eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P < 0.05 was considered to be significant.Results:
Ovariectomy induced statistically significant lower BAD values (p = 0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy.Conclusions:
Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group
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